| Pair Name | Cinnamaldehyde, Dacarbazine | ||
| Phytochemical Name | Cinnamaldehyde (PubChem CID: 637511 ) | ||
| Anticancer drug Name | Dacarbazine (PubChem CID: 135398738 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Cinnamaldehyde, Dacarbazine | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Inhibition-->Glycolysis | |||
| Gene Regulation | Down-regulation | Expression | ENO1 | hsa2023 |
| In Vitro Model | A-375 | Amelanotic melanoma | Homo sapiens (Human) | CVCL_0132 |
| In Vivo Model | A375 cells (1×10⁷) were injected into nude mice. When the tumors had formed for one week, the mice were treated with DITC (25, 50, or 100 mg/kg/day) and CA (15, 30, or 60 mg/kg/day). | |||
| Result | As a covalent inhibitor of ENO1, CA combined with DTIC may be beneficial in patients with drug resistance in antimelanoma therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine. Cancers (Basel). 2020 Jan 29;12(2):311. doi: 10.3390/cancers12020311. | Click |
